报告题目：Megamolecules Design, Synthesis and Applications

报 告 人：Prof. Milan Mrksich Northwestern University

报告时间：2019年10月3日 下午3:00-4:30

报告地点：英士楼205会议室

Abstract：

The megamolecules offer new approaches for preparing scaffolds that can spatially organize protein domains. In this talk, We will describe an approach for synthesizing megamolecules that have sizes greater than 100 nm and yet are structurally perfectly defined. The approach relies on the selective and covalent reaction of an enzyme domain with an irreversible linker. Several enzyme-inhibitor pairs have been developed, and used to prepare megamolecules that are linear, cyclic, branched, and that have molecular weights greater than 500,000 Dalton, and sizes greater than 100 nm. We will describe the use of this approach to create synthetic antibodies for therapeutic applications, and outline routes to a broad array of functional molecules. This talk will include a discussion of applications of this method to prepare nanoscale membranes having biological functions.

Personal profile：

Milan Mrksich is the Henry Wade Rogers Professor at Northwestern University. He earned a BS degree from the University of Illinois and a PhD from Caltech. Then he served as a Postdoctoral Fellow at Harvard University before joining the faculty at the University of Chicago in 1996, where he remained until his move to Northwestern in 2011. His laboratory has pioneered several technologies, including strategies to integrate living cells with microelectronic devices, methods to enable high throughput assays for drug discovery, and approaches to making synthetic proteins for applications as therapeutics. Most notably, he developed the SAMDI biochip technology that allows enzymes to be tested at a rate of a hundred thousand per day. His work has been described in approximately 200 publications and 500 invited talks. His many honors include the Camille Dreyfus Teacher-Scholar Award, the TR100 Innovator Award, Arthur C. Cope Scholar Award, Pittsburgh Analytical Chemistry Award, and the Illinois Bio ICON Innovator Awardee.