报告题目：Genomic aspects on thermotolerance and thermal adaptation, and application of thermotolerant microbes for biofuel production

报 告 人：Prof . Mamoru Yamada Yamaguchi University

报告时间：2019年09月27日 下午2:00-3:30

报告地点：英士楼101会议室

Abstract：The global temperature is increasing due to emission of greenhouse gas. Carbon dioxide as its main constituent comes from utilization of fossil fuels including coal, petroleum and natural gas. Thus, the reduction of carbon dioxide emission becomes an urgent issue and increased use of biofuels is recommended. Since the worldwide demand for bioethanol is rising, energy-saving, efficient ethanol production technologies should be developed for utilization of various biomass species. As one of such technologies, high-temperature fermentation (HTF) is considered, which is expected to have advantages including reduction of cooling cost and saving water during the fermentation process, which consequently cut down the total running cost. For HTF, however, the development of thermotolerant and efficient microbes is essential. We have thus screened thermotolerant microbes from tropical environments. On the other hand, in order to understand molecular mechanism of thermotolerance of such microbes, we analyzed genes responsible for survival at critical high temperatures. Moreover, to further improve thermotolerance, thermal adaptation of isolated thermotolerant microbes was performed and responsible genes for the adaptation were identified. The evaluation method of improvement of thermal stability has also been developed. Furthermore, transcriptomic and morphological analyses revealed that thermotolerant yeast changes metabolism, which would be strategy for thermal stability. We have also focused on the development of high-temperature fermentation technology for ethanol production and advanced fermentation processes including a temperature-uncontrolled fermentation and a simultaneous fermentation and distillation under a low pressure.