报告题目：Combined Metal and Enzyme Catalysis in Organic Synthesis. Examples of Artificial Metalloenzymes
报 告 人：Prof. Jan-E Bäckvall Stockholm University
报告时间：2019年10月15日 下午3:30-5:00
报告地点：英士楼319会议室
Curriculum Vitae：
Prof. Bäckvall is a Member of the Royal Swedish Academy of Sciences, Finnish Academy of Science and Letters, and Academia European. In 2008-2016, he was a member of the Nobel Committee for Chemistry. He is a member of a number of Editorial Boards for scientific journals.
Prof. Bäckvall is renowned for his contribution to organopalladium chemistry and catalytic oxidation reactions where he has done mechanistic work and developed new reactions. He has also pioneered the development of efficient systems for dynamic kinetic resolution of alcohols and amines based on combined metal and enzyme catalysis. More recently the enantioselectivity of enzymes was improved by directed evolution. The Bäckvall group has also developed a variety of useful aerobic biomimetic oxidation reactions. In these reactions electron-transfer mediators are employed to facilitate low-energy electron transfer similar to that occurring in natural systems. Recent applications of the latter topic involve palladium-catalyzed oxidative carbocyclizations. He has published more than 500 papers and given more than 175 plenary and main lectures at international conferences.
Selected Publications:
[1] Y. Qiu, B. Yang, C. Zhu, and J.-E. Bäckvall. Highly Efficient Cascade Reaction for Selective Formation of Spirocyclobutenes from Dienallenes via Palladium-Catalyzed Oxidative Double Carbocyclization-Carbonylation-Alkynylation”. J. Am. Chem. Soc. 2016, 138, 13846–13849.
[2] Y. Qiu, D. Posevins, and J.-E. Bäckvall. Highly Selective Palladium-Catalyzed Allenic C–H Bond Oxidation for Synthesis of Dendralenes. Angew. Chem. Int. Ed. 2017, 56, 13112–13116.
[3] Bartholomeyzik, R. Pendrill, R. Lihammar, T. Jiang, G. Widmalm, and J.-E. Bäckvall. Kinetics and Mechanism of the Palladium-Catalyzed Oxidative Arylating Carbocyclization of Allenynes. J. Am. Chem. Soc. 2018, 140, 298–309.