王怡助理教授

硕士生导师

电话：

邮箱：wangyi671@mail.tsinghua.edu.cn

致力于天然活性多糖与多肽药物创制，以及微流控类器官培养技术、装备及其应用等方面的研究。综合利用生命科学以及医药工程科学的原理和技术，在分子、细胞、组织、器官至人体系统多层次系统开展药物成分、结构、功能以及体内代谢等方面的研究，并发展高效挖掘天然功能性多糖与多肽结构与功能的新方法和新装备。目前已在Carbohydrate Polymer、Food Chemistry、Food Science and Human Wellness、Cancer Medicine以及Cell Biochemistry and Function等SCI收录刊物上发表论文20余篇，公开和授权发明专利12项，负责或参与科技部、国家自然科学基金委员会以及地方基金等项目13项。

● 教育与工作经历

2003年9月-2008年6月河北医科大学中西医临床医学，本科，学士

2009年4月-2014年3月日本大阪大学病理学，硕博连读，博士

2014年4月-2015年10月日本大阪大学医学院先端医疗科学转化中心，特任研究员

2015年11月-2018年11月清华大学化工系生物化工研究所，博士后

2018年12月-至今清华大学化工系生物化工研究所，助理教授

2021年12月-至今清华大学无锡应用技术研究院中心主任

● 研究领域

多糖与多肽药物、人源性类器官培养、类器官微流控芯片

● 主要学术任职

《Journal of Future Foods》青年编委
《食品工业科技》青年编委
《食品研究与开发》青年编委

● 代表性论文

1. Zeng Wen, He Dong, Xing Yifan, Liu Junyu, Su Nan, Zhang Chong, Wang Yi*, Xing XinHui*, Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review, Food Science and Human Wellness, 2021, 10:119-130.

2. Jun-Yu Liu, Dong He, Yi-Fan Xing, Wen Zeng, Kai Ren, Chong Zhang, Yuan Lu, Song Yang, Shu-Jian Ou, Yi Wang*, Xin-Hui Xing*, Effects of bioactive components of Pu-erh tea on gut microbiomes and health: A review. Food Chemistry, 2020, 353: 129439.

3. Yang Ji#; Yi Wang#; Wen Zeng; Xiang Mei; Shanshan Du; Yishu Yan; Jie Hao; Zhenqing Zhang; Yuan Lu; Chong Zhang; Jun Ge; Xin-Hui Xing*;A heparin derivatives library constructed by chemical modification and enzymatic depolymerization for exploitation of non-anticoagulant functions, Carbohydrate Polymers, 2020, 249: 116824.

4. Yifan XING#, Junyu LIU#, Xiaojie GUO, Haipeng LIU, Wen ZENG, Yi WANG, Chong ZHANG, Yuan LU, Dong HE, Shaohua Ma, Yonghong He, Xin-Hui XING；Engineering organoid microfluidic system for biomedical and health engineering: a review；Chinese Journal of Chemical Engineering, 2021, 30:244-254.

5. Yuting Li, Dong He, Bing Li, Marianne. Lunde, Yifan Xing, Yi Wang, Fuxiang Li, Xiao Cao, Yujia Liu, Xiangyu Chen, Jiamei Yu, Jie Zhu, Minlian Zhang, Qiang Wang, Yuhao Zhang, Bin Li, Jinshui Wang, Xinhui Xing, Lin Li, Engineering polyphenols with biological functions via polyphenol-protein interactions as additives for functional foods, Trends in Food Science & Technology, 2021, 110: 470-482.

6. He Dong, Peng Xue, Xing Yi-Fan, Wang Yi, Zeng Wen, Su Nan, Zhang Chong, Lu Dian-Nan, Xing Xin-Hui, Increased stability and intracellular antioxidant activity of chlorogenic acid depend on its molecular interaction with wheat gluten hydrolysate, Food Chemistry, 2020, 325: 126873.

7. Fu Yanxia, Kong Yanhua, Li Jun, Wang Yi, Li Mengdi, Wang Ying, Wang Yinyin, Ren Fangli, Ni Jian, Li Yonglin, Chang Zhijie. Mesenchymal stem cells combined with traditional Chinese medicine (qi-fang-bi-min-tang) alleviates rodent allergic rhinitis. J Cell Biochem. 2020, 121(2):1541-1551.

8. Dong He, Yi Wang, Jun Lin, Yi-Fan Xing, Wen Zeng, Wen-Ming Zhu, Nan Su, Chong Zhang, Yuan Lu, Xin-Hui Xing*, Identification and characterization of alcohol-soluble components from wheat germ-apple fermented by Lactobacillus sp. capable of preventing ulcerative colitis of dextran sodium sulfate-induced mice, Journal of Functional Foods, 2019, 64:103642.

9. 周雪，王怡，何东，曾文，张翀，薛正莲，邢新会，口服肝素与小鼠肠道菌群的相互作用，生物工程学报，2019，35(9): 1736−1749.

10. Yan-Shen Kuang#; Yi Wang#; Li-Dan Ding; Liu Yang; Ying Wang; Si-Han Liu; Bing-Tao Zhu; Xu-Ning Wang; Hong-Yi Liu; Jun Li; Zhi-Jie Chang; Yin-Yin Wang; Bao-Qing Jia*, Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil, World Journal of Gastroenterol, 2018, 24(4): 475-483.

11. Yi-Fan Xing, Dong He, Yi Wang, Wen Zeng, Chong Zhang, Yuan Lu, Nan Su, Yan-Hua Kong, Xin-HuiXing, Chemical Constituents, Biological Functions and Pharmacological Effects for Comprehensive Utilization of Eucommia ulmoides Oliver, Food Science and Human Wellness, 2019, 8:177-188.

12. Wenming Zhu, Yang Ji, Yi Wang, Dong He, Yishu Yan, Nan Su, Chong Zhang, Xin-Hui Xing, Structural characterization and in vitro antioxidant activities of chondroitin sulfate purified from Andrias davidianus cartilage, Carbohydrate Polymers, 2018, 196: 398-404.

13. Dong He, Wenming Zhu, Wen Zeng, Jun Lin, Yang Ji, Yi Wang, Chong Zhang, Yuan Lu, Dao quan Zhao, Nan Su, Xin-Hui Xing, Nutritional and medicinal characteristics of Chinese giant salamander (Andrias davidianus) for applications in healthcare industry by artificial cultivation: A review, Food Science and Human Wellness, 2018, 7:1-10.

14. Jian Li, Amber R. Smith, Rebecca T. Marquez, Jun Li, Kun Li, Lan Lan, Xiaoqing Wu, Linxi Zhao, Fangli Ren, Yi Wang, Yinyin Wang, Baoqing Jia, Liang Xu, Zhijie Chang. Mol Carcinog. 2018 Oct;57(10):1408-1420. MicroRNA-383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression. Molecular Carcinogenesis, 2018, 57:1408-1420.

15. Li Chunlei; Fu Yanxia; Wang Yinyin; Kong Yanhua; Li Mengdi; Ma Danhui; Zhai Wanli; Wang Hao; Lin Yuting; Liu Sihan; Ren Fangli; Li Jun; Wang Yi*, Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats, Cell Biochemistry and Function, 2017, 35(7): 420-425.

16. Y Jiang, H Li, Y Wang, T Tian, Y He, Y Jin, C Han, X Jin, F Zhang, E Morii. ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line, Oncol Lett, 2017, 14: 6955-6961.

17. Yan Y, Du S, Ji Y, Su N, Wang Y, Mei X, Zhu W, He D, Lu Y, Zhang C, Xing XH. Discovery of enzymatically depolymerized heparins capable of treating Bleomycin-induced pulmonary injury and fibrosis in mice, Carbohydr Polym, 2017, 174:82-88.

18. Yan Y, Ji Y, Su N, Mei X, Wang Y, Du S, Zhu W, Zhang C, Lu Y, Xing XH. Non-anticoagulant effects of low molecular weight heparins in inflammatory disorders: A review, Carbohydr Polym, 2017, 60:71-81.

● 授权专利

1. 邢新会；朱文明；王怡；何东；张翀；苏楠；大鲵软骨素制剂,中国发明专利，201810728741.X，2020/10/23

2. 邢新会；闫佚姝；季洋；王怡；低分子量肝素以及肝素用于制备肺纤维化的用途，中国发明专利，201710374727.X，2020/04/14

3. 邢新会；闫佚姝；季洋；王怡；低分子量肝素以及肝素用于制备肺纤维化的用途，中国发明专利，201710374073.0，2020/02/21