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李 春 教授博士生导师 杰出青年基金获得者
电话：010-62799893 邮箱：lichun@tsinghua.edu.cn |
长期开展1）天然产物的微生物合成与生物转化；2）工业微生物的抗逆重编程与工程应用；3）生物催化与酶工程。国家重点研发计划“合成生物学”专项首席科学家。担任中国化工学会生物化工专委会副主任、中国生物工程学会科普工作委员会主任、工业与环境生物技术专业委员会副主任、中国生物工程学会合成生物学专委会副主任；担任《合成生物学》执行主编、《Frontiers in Bioengineering and Biotechnology》副主编、《Applied Microbiology and Biotechnology》、《Synthetic and Systems Biotechnology》、《化工进展》、《催化学报》、《过程工程学报》、《农业工程学报》、《生物加工过程》等期刊编委。
● 教育与工作经历
2001.08 –2003.10 清华大学 生物化工 博士后
1998.02 –2001.08 天津大学 生物化工 博士
1997.08 –1998.02 天津科技大学 发酵工程 进修
1997.07 –1997.08 中国农业大学 食品生物技术 培训
1992.08 –1995.06 石河子大学 微生物学 硕士
1988.09 –1992.07 石河子大学 植物保护 学士
● 研究领域
1）代谢工程与合成生物学；2）生物催化与酶工程；3）细胞工厂的数字化设计
● 开设课程及编写教材
2005-2020年，讲授本科生“生物工程与技术导论”、“微生物学”和“酶工程与生物催化”；硕士生“合成生物学”和“现代生物技术”；博士生“生物分子工程”等课程
2020年至今，讲授本科生“生物化学”和《分子生物学》，研究生《合成生物学》
主编教材《合成生物学》、《生物工程与技术导论》和《Introduction to Biochemical Engineering》
副主编教材《生物化学》（国家级精品教材）和《细胞培养工程》
● 主要学术任职
国家重点研发计划“合成生物学”专项首席科学家。
中国生物工程学会常务理事，合成生物学分会副理事长，工业与环境生物技术专业委员会副主任，科普工作委员会主任；中国化工学会生物化工专委会副主任。
《合成生物学》执行主编；《Frontiers in Bioengineering and Biotechnology》副主编；《Applied Microbiology and Biotechnology》、《Synthetic and Systems Biotechnology》、《化工进展》、《催化学报》、《过程工程学报》、《农业工程学报》、《生物加工过程》等期刊编委；《BioDesign Research》顾问编委。
● 代表性论文
1. Gao Bo†, Yang Bo†, Feng Xudong*, Li Chun*. Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products, Natural Product Reports, 2022, 39, 139-1622.
2. Muhammad Saad, Chun Li*. Efflux Transporters' Engineering and Their Application in Microbial Production of Heterologous Metabolites. ACS Synth Biol. 2021, 10(4):646-669.
3. Liu Mingzhu, Yu Jing, Lv Bo*, Hou Yuhui, Liu Xinhe, Feng Xudong*, Li Chun *. Improving the activity and thermostability of GH2 β-glucuronidases via domain reassembly. Biotechnol Bioeng. 2021, 118(5): 1962-1972.
4. Akram Muhammad, An Ting, Feng Xudong*, Li Chun*. Metabolic engineering of Yarrowia lipolytica for liquiritigenin production, Chemical Engineering Science, 2021, (230) 116177
5. Sun Wentao, Xue Haijie, Liu Hu, Lv Bo, Yu Yang*, Wang Ying*, Huang Meilan, Li Chun*, Controlling chemo- and regioselectivity of a plant P450 in yeast cell toward rare licorice triterpenoid biosynthesis. ACS Catalysis 2020, 4253-4260.
6. Xu Ke, Zhao Yu-jia, Lv Bo*, Wang Ying, Ge Jun, Li Chun*. O-glycosyltransferases from Homo sapiens contributes to the biosynthesis of Glycyrrhetic Acid 3-O-mono-β-D-glucuronide and Glycyrrhizin in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2021 (6): 173–179
7. Qin Lei and Li Chun*, et al. Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation. Metabolic Engineering, 2020, 61:160-170.
8. Liu Hu, Cao Mingming, Wang Ying, Lv Bo and Li Chun*. Bioengineering oligomerization and monomerization of enzymes: learning from natural evolution to matching the demands for industrial applications. Critical Reviews in Biotechnology, 2020, 40(2):231-246
9. Xu Ke, Qin Lei, Bai Wenxin, Wang Xiaoyan, Li Fan, Ren Shichao, Gao Xiaopeng, Chen Bo, Tong Yi, Li Jun, Li Bing-Zhi, Yuan Ying-Jin, and Li Chun*. Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae. ACS Energy Lett. 2020, 5, 572−582
10. Ming Zhu, Caixia Wang, Wentao Sun, Anqi Zhou, Ying Wang, Genlin Zhang, Xiaohong Zhou, Yixin Huo, Li Chun*. Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system. Metabolic Engineering, 2018, 45, 43-50.
11. Ke Xu，Bo Lv，Yi-Xin-Huo，Li Chun*. Toward the lowest energy consumption and emission in biofuel production: combination of ideal reactors and robust hosts. Current Opinion in Biotechnology, 2018, 50: 19-24.
12. Lv Bo, Sun Hanli, Huang Shen, Feng Xudong, Jiang Tao, Li Chun*. Structure-guided engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins. Journal of Biological Chemistry, 2018, 93(2):433-443.
13. Yu Yuan, Chang Pengcheng, Yu Huan, Ren Huiyong, Hong Danning, Li Zeyan, Wang Ying, Song Hao, Huo Yixin and Li Chun*. Productive Amyrin Synthases for Efficient α-amyrin Synthesis in Engineered Saccharomyces cerevisiae. ACS Synthetic Biology, 2018, 7(10), 2391-2402.
14. Xudong Feng, Xiaoyan Wang, Beijia Han, Changling Zou, Yuhui Hou, Lina Zhao and Chun Li*. Design of Glyco-Linkers at Multiple Structural Levels to Modulate Protein Stability. The Journal of Physical Chemistry Letters. 2018, 9, 4638−4645
15. Xu Yinghua, Feng Xudong, Jia Jintong, Chen Xinyi, Jiang Tian, Rasool Aamir, Lv Bo, Qu Liangti, Li Chun*. A Novel β-Glucuronidase from Talaromyces pinophilus Li-93 Precisely Hydrolyzes Glycyrrhizin into Glycyrrhetinic Acid 3-O-Mono-β-d-Glucuronide. Applied and Environmental Microbiology, 2018,84(19):00755-18
16. Zhao Yujia, FanJingjing, Wang Chen, Feng Xudong*, Li Chun*. Enhancing oleanolic acid production in engineered Saccharomyces cerevisiae. Bioresource Technology. 2018 (257) :339–343.
17. Yinghua Xu, Yanli Liu, Aamir Rasool, Wenwen E, Li Chun*. Sequence Editing Strategy for Improving Performance of β-glucuronidase from Aspergillus terreus. Chemical Engineering Science, 2017, 167: 145-153.
18. Jia Haiyang, Sun Xiangying, Sun Huan, Li Chenyi, Wang Yunqian, Feng Xudong, Li Chun*. Intelligent Microbial Heat-Regulating Engine (IMHeRE) for Improved Thermo-Robustness and Efficiency of Bioconversion. ACS Synthetic Biology, 2016, 5(4): 321-320.
19. Aamir Rasool, Genlin Zhang, Zhe Li, Li Chun*. Engineering of Terpenoid Pathway in Saccharomyces cerevisiae Cooverproduce Squalene and Oleic acid. Chemical Engineering Science, 2016, 152:457-467
20. Zhang Genlin, Cao Qian, Liu Jingzhu, Liu Baiyang, Li Jun, Li Chun*. Refactoring ß-amyrin synthesis in Saccharomyces cerevisiae. AIChE Journal. 2015, 61(10): 3172-3179.
21. Li Zhe, Guo Xiaoxiao, Feng Xudong, Li Chun*. An environment friendly and efficient process for xylitol bioconversion from enzymatic corncob hydrolysate by adapted Candida tropicalis. Chemical Engineering Journal. 263 (2015) 249–256
● 学术荣誉与奖励
2004年 入选教育部“新世纪优秀人才计划”
2005年 获“霍英东青年基金奖”
2006年 享受国务院政府特殊津贴
2014年 获得国家杰出青年科学基金
2017年 获得“侯德榜化工科技创新奖”
2017年 遴选为全国“生物工程学”首席科学传播专家
2012-2019年 组织并指导大学生的合成生物学作品连续7年获得美国MIT主办的“国际遗传工程机器竞赛” （iGEM）金奖
获省部级科技成果奖励4项