卢元课题组研究的中心模式是利用工程学、生物学、化学、物理学、数学和计算机科学等多学科交叉手段操作生物大分子和复杂的生物网络。研究的焦点在于发展和应用世界最前沿的技术，突破天然生命体系的限制，快速改造生物分子机器、细胞和系统网络，以解决生物制造、人类健康等领域最具挑战性的工程难题。卢元博士目前在PNAS、Small、ACS Synthetic Biology等杂志上已发表80多篇高影响学术杂志论文，多项国际国内授权专利。参加的科研项目受到了重大项目机构的支持，包括科技部重点研发计划、自然科学基金等。
● 教育与工作经历
2000-2004 清华大学化工系，学士
2004-2009 清华大学化工系，博士
2009-2010 美国约翰霍普金斯大学，博士后
2010-2014 美国斯坦福大学，博士后
2014-2016 日本东京大学，特任研究员
2016-2019 清华大学化工系，PI/助理教授
2019-至今 清华大学化工系，PI/副教授
● 研究领域
无细胞合成生物学、RNA/蛋白质制造、人工细胞、神经传感、微纳智能机器
● 开设课程
《生物化学原理》，本科生课程
● 主要学术任职
BioDesign Research 副主编
Journal of Future Foods 副主编
Frontiers in Bioengineering and Biotechnology 副主编
Synthetic and Systems Biotechnology 编委
Biotechnology Notes 编委
Bioresources and Bioprocessing 编委
● 代表性论文
1. Dong Liu, Ting Zhang, Xiaowen Cheng, Bin Wang, Yijia Guo, Zhengzuo Liu, Hao Jiang, Yuan Lu*. Engineering pollen-derived microstructures to reveal material morpho-performance paradigm. Small, 2022: 2200037.
2. Yuan Lu*. Textile-embedded cell-free biosensors. Nature Biomedical Engineering, 2022, 6 225-226.
3. Junzhu Yang#, Chen Wang#, Yuan Lu*. A temperature-controlled cell-free expression system by dynamic repressor. ACS Synthetic Biology, 2022, doi: 10.1021/acssynbio.1c00641
4. Shangsong Li#, Dong Liu#, Yuping Hu#, Zhijie Su, Xinai Zhang, Ruirui Guo, Dan Li, Yuan Lu*. Soft magnetic microrobot doped with porous silica for stability-enhanced multimodal locomotion in a nonideal environment. ACS Applied Materials & Interfaces, 2022, 14(8): 10856-10874.
5. Dong Liu#, Ting Wang#, Yuan Lu*. Untethered microrobots for active drug delivery: from rational design to clinical settings. Advanced Healthcare Materials, 2022, 2102253.
6. Jiaqi Hou#, Xinjie Chen#, Nan Jiang#, Yanan Wang, Yi Cui, Lianju Ma*, Ying Lin*, Yuan Lu*. Toward efficient multiple-site incorporation of unnatural amino acids using cell-free translation system. Synthetic and Systems Biotechnology, 2022, 7(1): 522-532.
7. Xinjie Chen, Yuan Lu*. Circular RNA: Biosynthesis in vitro. Frontiers in Bioengineering and Biotechnology, 2021, 9: 787881.
8. Chen Wang#, Junzhu Yang#, Yuan Lu*. Modularize and unite: Toward creating a functional artificial cell. Frontiers in Molecular Biosciences, 2021, 8: 781986.
9. Dong Liu#, Shangsong Li#, Ting Zhang, Hao Jiang, Yuan Lu*. 3D magnetic field-controlled synthesis, collective motion, and bioreaction enhancement of multifunctional peasecod-like nanochains. ACS Applied Materials & Interfaces, 2021, 13: 36157-36170.
10. Xinjie Chen#, Yingying Liu#, Jiaqi Hou#, Yuan Lu*. A linear DNA template-based framework for site-specific unnatural amino acid incorporation. Synthetic and Systems Biotechnology, 2021, 6: 192-199.
11. Liyuan Zhang#, Xiaomei Lin#, Ting Wang#, Wei Guo*, Yuan Lu*. Development and comparison of cell-free protein synthesis systems derived from typical bacterial chassis. Bioresources and Bioprocessing, 2021, 8: 58.
12. Cheng-Yen Lin#, Yi Feng#, Jun Ge*, Yuan Lu*. Impact of metal–organic frameworks on protein expression. Chemical Research in Toxicology, 2021, 34: 1403-1408.
13. Xinjie Chen, Yuan Lu*. In silico design of linear DNA for robust cell-free gene expression. Frontiers in Bioengineering and Biotechnology, 2021, 9: 670341.
14. Xiaomei Lin, Zhixia Li, Yuting Li, Yuan Lu*. A robust Escherichia coli cell-free expression toolbox driven by sigma factors. Biochemical Engineering Journal, 2021, 171: 108031.
15. Nan Jiang#, Xuanwei Ding#, Yuan Lu*. Development of a robust Escherichia coli-based cell-free protein synthesis application platform. Biochemical Engineering Journal, 2021, 165: 107830.
16. Chen Wang#, Yuhao Geng#, Qi Sun#, Jianhong Xu*, Yuan Lu*. A sustainable and efficient artificial microgel system: Toward creating a configurable synthetic cell. Small, 2020: 2002313.
17. Junzhu Yang, Yuan Lu*. Physical stimuli-responsive cell-free protein synthesis. Synthetic and Systems Biotechnology, 2020, 5(4):363-368.
18. Eunhee Cho, Yuan Lu*. Compartmentalizing cell-free systems: Toward creating life-like artificial cells and beyond. ACS Synthetic Biology, 2020, 9(11): 2881-2901. (Front Cover Article)
19. Xiaomei Lin, Yuting Li, Zhixia Li, Rui Hua, Yuyang Xing, Yuan Lu*. Portable environment-signal detection biosensors with cell-free synthetic biosystems. RSC Advances, 2020, 10: 39261-39265.
20. Peng Zhang#, Junzhu Yang#, Eunhee Cho#, Yuan Lu*. Bringing light into cell-free expression. ACS Synthetic Biology, 2020, 9: 2144-2153. (Cover Article)
21. Liyuan Zhang, Wei Guo*, Yuan Lu*. Advances in cell-free biosensors: Principle, mechanism, and applications. Biotechnology Journal, 2020, 2000187 (Front Cover Article)
22. Nan Jiang, Lianju Ma*, Yuan Lu*. Cell-free synthetic biology in the new era of enzyme engineering. Chinese Journal of Chemical Engineering, 2020, 28(11):2810-2816.
23. Dong Liu, Zhenghuan Yang, Luyang Zhang, Minglun Wei, Yuan Lu*. Cell-free biology using remote-controlled digital microfluidics for individual droplet control. RSC Advances, 2020, 10: 26972-26981.
24. Xinjie Chen#, Qi Sun#, Yuan Lu*. Creating a locally crowded environment with nanoclay hydrogels for cell-free biosynthesis. Soft Matter, 2020, 16: 5132-5138. (Cover Article)
25. Xiaomei Lin#, Caijin Zhou#, Jisong Zhang*, Yuan Lu*. O2-tuned protein synthesis machinery in Escherichia coli-based cell-free system. Frontiers in Bioengineering and Biotechnology, 2020, 8: Article 312
26. Caijin Zhou#, Xiaomei Lin#, Yuan Lu*, Jisong Zhang*. Flexible on-demand cell-free protein synthesis platform based on a tube-in-tube reactor. Reaction Chemistry & Engineering, 2020, 5: 270-277 (Front Cover Article)
● 学术荣誉与奖励
2017年 第九届“侯德榜化工科技青年奖”
中国化工学会生物化工专业委员会首届青年学者论坛-优秀报告奖
2016年 ICMS 2016 青年科学家奖（Young Scholar Award）
● 实验室主页
www.LuGroup.net